Chemical Name: 3,4,5-Trimethoxybenzoic acid methyl ester
Synonyms: Methyl mesitiate; Methyl 3,4,5-trimethoxybenzoate
Molecular Formula: C11H14O5
Molecular Weight: 226.23 g/mol
CAS Number: 1916-07-0
Recommended Use: Chemical research, pharmaceutical intermediate, laboratory reagent
Supplier: Contact information for manufacturer or distributor
Emergency Contact: Local fire brigade, poison control center, emergency health provider
GHS Classification: Not classified as hazardous under GHS guidelines; always observe appropriate safety practises
Signal Word: None required under current classification
Hazard Statements: Possible irritation to skin, eyes, or respiratory system on direct contact
Pictograms: None mandated
Precautionary Statements: Avoid breathing dust, fumes, or vapour; prevent skin and eye contact; maintain adequate ventilation
Other Hazards: Fine particulate can become airborne; environmental exposure should be minimized; handle with typical laboratory precautions
Substance: 3,4,5-Trimethoxybenzoic acid methyl ester
Percent Purity: ≥98%
Impurities: Trace synthetic byproducts, not classified as hazardous at conventional concentrations
EC Number: 217-760-3
Inhalation: Remove exposed individual to fresh air; provide artificial respiration if not breathing; seek immediate medical attention if symptoms develop
Skin Contact: Remove contaminated clothing; wash skin thoroughly with soap and water; seek medical advice if irritation continues
Eye Contact: Rinse eyes with copious amounts of water for at least 15 minutes, lifting eyelids; prompt medical evaluation recommended
Ingestion: Rinse mouth with water; do not induce vomiting without medical instruction; consult physician if large amount is ingested or if symptoms occur
Notes for Physicians: Supportive care based on clinical condition; symptomatic treatment for irritation or allergic reactions
Suitable Extinguishing Media: Water spray, dry chemical, foam, carbon dioxide
Unsuitable Media: Direct water jet may spread fire or cause splatter
Specific Hazards: Emits toxic fumes of carbon oxides under combustion
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear
Advice for Firefighters: Move containers from fire area if it can be done without risk; prevent runoff from entering drains or watercourses; control breathing zone exposure
Personal Precautions: Use personal protective equipment, including gloves, goggles, and dust mask
Environmental Precautions: Avoid dispersal; confine spill to prevent environmental contamination; do not allow entry to water systems
Clean-Up Methods: Scoop or sweep up spill and collect for approved disposal; ventilate area; decontaminate the site with soap and water following removal
Reference to Other Sections: Refer to sections on personal protection and disposal for additional guidance
Handling: Work in well-ventilated environments with local exhaust; wear protective gear to avoid contact and inhalation; wash thoroughly after handling; avoid creating dust
Storage: Store in tightly sealed container in cool, dry, well-ventilated space away from incompatible materials such as strong oxidizers; segregate from food and animal feed; label containers clearly; maintain access to safety shower and eyewash stations
Control Parameters: No specific occupational exposure limit assigned
Engineering Controls: Use chemical fume hood or good general ventilation; install safety shower and eyewash
Personal Protective Equipment: Chemical-resistant gloves, lab coat, protective goggles; use NIOSH-approved respirator where risk of dust or aerosol exists
Hygiene Measures: Wash hands and face thoroughly before eating, drinking, or leaving work area; disallow eating or smoking around material
Appearance: White to off-white crystalline powder
Odour: Faint aromatic
Melting Point: 89–91 °C
Boiling Point: 290 °C (estimated, decomposes)
Solubility: Slightly soluble in water; soluble in ethanol, methanol, and organic solvents
Vapour Pressure: Not measured due to low volatility
Partition Coefficient: log Kow approx. 2.3
pH: Neutral aqueous solution
Flash Point: Over 120 °C
Decomposition Temperature: Not well defined; decomposes at elevated temperature
Reactivity: Not expected to exhibit significant reactivity under standard conditions
Chemical Stability: Shows stability at ambient temperature and pressure
Possible Hazardous Reactions: No hazardous polymerization anticipated
Materials to Avoid: Strong oxidizing agents, strong acids and bases
Conditions to Avoid: Excessive heat, open flame, incompatible chemicals
Hazardous Decomposition: Produces carbon monoxide, carbon dioxide upon combustion or thermal decomposition
Acute Toxicity: Not expected to be acutely toxic at anticipated exposure levels; low oral and dermal toxicity observed in studies
Skin Corrosion/Irritation: Possible mild skin irritation
Serious Eye Damage/Irritation: May cause discomfort or redness, no lasting injury expected
Respiratory Sensitisation: Dust may irritate upper respiratory tract
Carcinogenicity: No evidence available to suggest effects
Mutagenicity: Not classified as mutagenic
Reproductive Toxicity: Evidence lacking for adverse effects
Other Data: Symptoms related to exposure can include mild headache, sore throat, only at high concentrations; persons with allergies to similar compounds should use extra caution
Ecotoxicity: No data indicating toxicity to aquatic or terrestrial organisms at routine concentrations
Persistence and Degradability: Expected to remain for some time but gradually break down through environmental processes
Bioaccumulation: Moderate potential based on partition coefficient values
Mobility in Soil: Low to moderate due to low solubility
Other Adverse Effects: Product not classified as hazardous to the environment; spill management focuses on containment
Waste Treatment Methods: Disposal must comply with local, regional, and national regulations; consult waste management professionals
Contaminated Packaging: Containers should be triple-rinsed and rendered unusable before disposal; treat rinse water as hazardous
Recommended Disposal: Combustion in approved chemical incinerators with afterburner and scrubber; landfilling only when authorised and subjected to appropriate controls
Disposal Precautions: Do not discharge to sewers, drains, or natural water bodies
UN Number: Not classified as dangerous goods
Proper Shipping Name: 3,4,5-Trimethoxybenzoic acid methyl ester
Transport Hazard Class: None
Packing Group: None
Label: No hazard label required
Special Precautions: Protect containers from physical damage; avoid high temperatures and direct sunlight during transit
Environmental Hazards: Product not classified as marine pollutant
EU Regulations: Not listed as a substance of concern under REACH; safety data consistent with CLP regulation
US Regulations: Not regulated under SARA Title III, CERCLA, or TSCA for specific reporting
Canada: Not listed under WHMIS as controlled product
Other Regulations: Ensure compliance with workplace and environmental laws applicable to chemical handling and storage
Chemical Inventory Lists: Registered in many international regulatory databases; status regularly updated by suppliers for compliance
